thyroid peroxidase

About Thyroid Peroxidase

Thyroid peroxidase (TPO) is an enzyme found in the thyroid gland and is essential for the production of the hormones thyroxine (T4) and triiodothyronine (T3). It works by catalyzing the oxidation of iodide ions and coupling them to form the major thyroid hormones. A deficiency in TPO can cause hypothyroidism, in which the body does not produce the amount of hormones necessary to maintain bodily functions.

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Symptoms of Hypothyroidism

Hypothyroidism can cause a variety of symptoms that may not be immediately noticeable. These signs and symptoms can include:

  • Brittle hair and nails
  • Constipation
  • Depression
  • Dry skin
  • Fatigue
  • Fluid retention
  • Goiter
  • Hair loss
  • Intolerance to cold temperatures
  • Irregular menstruation
  • Muscle soreness
  • Puffy face
  • Slow heart rate
  • Weight gain

Diagnosing Thyroid Peroxidase Deficiency

The most common way to diagnose a deficiency in thyroid peroxidase is with a blood test. The test measures the amount of thyroid hormones in the blood and can detect any imbalance or deficiency. Depending on the results of the test, additional tests may be conducted to confirm the diagnosis.

Treatment for Thyroid Peroxidase Deficiency

Treatment for a deficiency in TPO typically involves taking a synthetic hormone replacement medication such as levothyroxine. This medication helps to restore the hormone imbalance in the body and can be taken as a tablet or as an injection. Other treatments may also be recommended to improve symptoms such as vitamins, diet changes and lifestyle modifications.


Thyroid Peroxidase, TPO, Thyroxine, T3, Hypothyroidism, Levothyroxine, Treatment, Diagnosis.

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