Hypogonadism and Prostate Cancer: Understanding the Relationship

Hypogonadism Prostate

and Health

Prostate cancer is a serious form of cancer that typically affects men over the age of 50. It is important to understand the connection between hypogonadism, a condition of reduced production of testosterone in the body, and prostate cancer and the effects it may have on a person’s health.

What is Hypogonadism?

Hypogonadism is a condition in which the testosterone levels in the body are lower than normal. This can be caused by issues within the testes, such as an injury or genetic defect, or it could be due to an issue with the pituitary gland, which regulates hormone production. There are two forms of hypogonadism, primary and secondary.

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Primary Hypogonadism

Primary hypogonadism is caused by a problem within the testes, which is often genetic or acquired. In this condition, the testes do not produce enough testosterone to meet the body’s needs.

Secondary Hypogonadism

Secondary hypogonadism is caused by a problem with the pituitary gland, which is responsible for sending signals to the testes to produce testosterone. In this case, the pituitary gland does not send the correct signals, resulting in reduced testosterone production.

The Relationship Between Hypogonadism and Prostate Cancer

Recent research has found a strong link between hypogonadism and prostate cancer. Low testosterone levels have been linked to increased risk of prostate cancer development and progression, as well as decreased overall survival rates.

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It is important to note that men with hypogonadism are not more likely to develop prostate cancer, however, they are more likely to have more aggressive disease and a poorer prognosis than those without hypogonadism.

How to Manage Hypogonadism and Lower the Risk of Prostate Cancer

There are several ways that a man can manage his hypogonadism in order to lower his risk of developing prostate cancer. These include:

  • Testosterone Replacement Therapy (TRT): This therapy is used to replace the missing testosterone in a man’s system in order to restore normal hormone levels. This can help to reduce the risk of prostate cancer, as well as improve overall health.
  • Diet and Exercise: Eating a healthy diet and exercising regularly can help to reduce the risk of prostate cancer, as well as improve overall health.
  • Medication: Certain medications may be prescribed in order to reduce the risk of prostate cancer. These medications can also help to manage any symptoms associated with hypogonadism.


Hypogonadism and prostate cancer are closely linked, and it is important for a man to understand the connection and how to manage both conditions in order to reduce his risk of developing prostate cancer. By following the steps outlined above and speaking to their doctor, men with hypogonadism can manage their condition in order to lower their risk of developing this serious form of cancer.