Common Medications That Can Interact with Thyroxine (T4) Levels

Common Medications

and Health

Thyroxine, also known as T4, is a hormone produced by the thyroid gland. It is responsible for the regulation of metabolism, growth, and development of the body. Unfortunately, some medications can interfere with thyroxine (T4) levels. If taken without monitoring, these medications can affect the overall health of an individual.

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Drugs That Can Interact with T4 Levels

The following drugs can interact with T4 levels and should be used with caution:

  • Hypothalamic-releasing hormones: These hormones, including corticotropin-releasing hormone, luteinizing hormone-releasing hormone, and thyrotropin-releasing hormone, can inhibit the production of T4.
  • Iron: Oral iron supplements can inhibit T4 absorption.
  • Calcium and magnesium: These minerals, which are taken as supplements or found in antacids, can reduce the absorption of T4.
  • Anabolic steroids: These drugs, used to increase muscle mass and strength, can decrease T4 levels.
  • Ketoconazole: This antifungal drug can block T4 production.
  • Beta blockers: Beta blockers, used to treat high blood pressure, can also reduce T4 levels.

Risks of Low T4 Levels

Low levels of T4 can interfere with the body’s metabolism leading to a variety of health problems and symptoms, including:

  • Fatigue
  • Weight gain
  • Depression
  • Anxiety
  • Dry skin and hair
  • Constipation
  • Muscle weakness
  • Slowed heart rate
  • Hair loss


It is important to be aware of the drugs that can interact with thyroxine (T4) levels. If necessary, consult your doctor before taking any medications to ensure it will not interfere with T4 levels. Doing so can help maintain a healthy lifestyle and prevent any long-term health complications.